Linkage and association between HLA and 21-hydroxylase deficiency.
نویسندگان
چکیده
Congenital adrenal hyperplasia because of 21-hydroxylase deficiency is closely linked to the HLA system. The lod scores in 14 informative families are presented. Apart from linkage, the 21-hydroxylase deficiency is associated with an increase of BW47 antigen and lack of B8 antigen in patients. A family with a possible recombination between the 21-hydroxylase deficiency and the HLA complex was found, thus indicating that the 21-hydroxylase gene lies outside the HLA system and is closely linked to the HLA-DR locus.
منابع مشابه
Genetics and biochemical variability of variants of 21 hydroxylase deficiency.
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 17 5 شماره
صفحات -
تاریخ انتشار 1980